Chemotherapy or chemo is a type of cancer treatment done using drugs. These drugs kill the rapidly growing and dividing cancer cells, and prevent the cancer cells from growing and making more cells.
The normal cells of a healthy body are constantly dividing, growing, and dying. When cancer develops, the cells tend to reproduce uncontrollably and do not die on their own.
The chemotherapy drugs interfere with the ability of the cancer cells to divide and reproduce. The doctor may recommend a single drug or a combination of drugs to kill the cancer cells.
Types:
The different types of chemotherapy drugs include:
Cancer treatment: Chemotherapy can be used as a sole treatment option to treat cancer.
Adjuvant therapy: Chemotherapy can be after other cancer treatments like surgery and radiation therapy (use of high-energy radiation beams to kill the cancer cells), to kill any hidden cancer cells that may remain in the body.
Neoadjuvant therapy: Chemotherapy can be used to shrink the size of a tumor before starting with other forms of treatment like surgery and radiation therapy.
Palliative chemotherapy: Chemotherapy may be used to relieve the symptoms of cancer by killing some cancer cells.
Chemotherapy can be used for the treatment of conditions other than cancer, like:
Immune system disorders: Low doses of chemotherapy drugs can help in controlling an overactive immune system or disease-fighting system of the body in conditions like lupus (when the immune system of the body affects the joints, kidneys, skin, blood cells, brain, heart, and lungs of a person) and rheumatoid arthritis (an inflammatory disorder that mainly affects the joints).
Bone marrow diseases: Diseases affecting the blood cells and bone marrow (soft tissue found at the center of most bones) of an individual can be treated with a bone marrow transplant (the bone marrow of a person is replaced by a donor bone marrow), also called stem cell transplant. Chemotherapy may be used as a preparation for bone marrow transplant.
Physical examination: The doctor will check the physical health of the patient, and note the symptoms, medical history, and family history of the patient.
Blood tests: These tests help in checking the liver and kidney functions. The patient’s health can be assessed using these tests.
Tissue biopsy: The doctor excises a small part of the suspected tumor and sends it to the laboratory for examination.
FNAC / Fine needle aspiration cytology: A thin needle is inserted by the doctor into the growth lump and then examined under a microscope.
The type of chemotherapy drug given depends on the stage and type of cancer if there were any previous cancer treatments, the preferences, and overall health of the patient.
Based on what drugs are given, the doctor will determine how often chemotherapy treatments can be given. The schedule of chemotherapy treatment varies. The treatment may be continuous, or it may alternate between periods of treatment, known as chemotherapy cycles, and rest.
Chemotherapy can be provided in the following different ways:
1. Chemotherapy infusions:
Chemotherapy drugs are most commonly given as an infusion into a vein (intravenously).
The drugs are given by the insertion of a tube with a needle into a vein in the arm, or into a device in a vein in the chest.
2. Chemotherapy pills:
Some chemotherapy drugs can be taken in a capsule or pill form.
3. Chemotherapy shots:
Some chemotherapy drugs can be injected using a needle, just like receiving a shot.
4. Chemotherapy creams:
Gels or creams consisting of chemotherapy drugs can be applied to the skin (topically) for the treatment of certain types of skin cancer.
5. Chemotherapy drugs for the treatment of one area of the body:
Some chemotherapy drugs can be directly administered to one area of the body.
For example, chemotherapy drugs can be given directly in the chest cavity (intrapleural chemotherapy), abdomen (intraperitoneal chemotherapy), central nervous system (intrathecal chemotherapy), or into the bladder (where urine is stored) through the urethra (from where urine is removed) (intravesical chemotherapy).
6. Chemotherapy drugs given directly to the cancer site:
Chemotherapy drugs can be given directly to the site of the tumor, or post-surgery where cancer once was.
Chemotherapy drugs can also be injected into an artery or vein that feeds the tumor directly.
Nausea
Vomiting
Hair loss
Diarrhea
Fatigue
Loss of appetite
Fever
Pain
Mouth ulcers or sores
Pain
Bleeding
Easy bruising
Constipation
Long-term side effects that may develop much later may include:
Heart problems
Lung tissue damage
Infertility
Kidney problems
Nerve damage (peripheral neuropathy)
Risk of developing a second cancer
It is normal to feel fatigued or tired after chemotherapy.
The doctor may prescribe some painkillers to relieve your discomfort.
Include protein-rich foods in your diet after chemotherapy to maintain your weight.
Increase the intake of multivitamins, as per the doctor's recommendation.
Limit the consumption of salty foods and red meat after chemotherapy.
Avoid extended exposure to sunlight or UV rays after chemotherapy.
Use sunscreen of a good SPF level when stepping out.
Increase your physical activity gradually after chemotherapy.
Quit smoking.
Limit the consumption of alcohol.
MBBS, MD, DNB - Oncologist/Cancer Specialist
MBBS, - Oncologist/Cancer Specialist